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AUGMENTIN TABLETS- ANTIBIOTICS

AUGMENTIN 875 MG TABLET ( BRAND ) BY GLAXOSMITHKLINE contains 875 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as the potassium salt ( 1g tablet )

BUY	AUGMENTIN 875:125 (1G TABLET)	14 TABLETS	$ 70
BUY	AUGMENTIN 875:125 (1G TABLET)	28 TABLETS	$ 130
BUY	AUGMENTIN 875:125 (1G TABLET)	42 TABLETS	$ 170

AUGMENTIN 500 MG TABLET ( BRAND ) BY GLAXOSMITHKLINE contains 500 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as the potassium salt ( 625mg tablet )

BUY	AUGMENTIN 500:125 (625MG TABLET)	30 TABLETS	$ 70
BUY	AUGMENTIN 500:125 (625MG TABLET)	60 TABLETS	$ 130

AUGMENTIN 250 MG TABLET ( BRAND ) BY GLAXOSMITHKLINE contains 250 mg amoxicillin as the trihydrate and 125 mg clavulanic acid as the potassium salt ( 375mg tablet )

BUY	AUGMENTIN 250:125 (375MG TABLET)	20 TABLETS	$ 55
BUY	AUGMENTIN 250:125 (375MG TABLET)	40 TABLETS	$ 100
BUY	AUGMENTIN 250:125 (375MG TABLET)	60 TABLETS	$ 140

AUGMENTIN TABLET

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Augmentin Description : Each 375-mg tablet contains amoxycillin 250 mg and clavulanic acid 125 mg. Each 625-mg tablet contains amoxycillin 500 mg and clavulanic acid 125 mg. Each 1-g tablet contains amoxycillin 875 mg and clavulanic acid 125 mg. Each 5 mL of 156, 228 and 457 mg of reconstituted syrup contains amoxycillin 125, 200 and 400 mg and clavulanic acid 31.25, 28.5 and 57 mg, respectively. Each 5 mL of reconstituted solution contains amoxycillin 125 mg and clavulanic acid 31.25 mg. Each 600-mg and 1.2-g vial contains amoxycillin 500 and 1 g and clavulanic acid 100 mg and 200 mg, respectively. Augmentin syrup also contains aspartame. Augmentin 228- and 457-mg syrup when reconstituted forms an oral sugar-free syrup. Augmentin preparations do not contain sucrose, tartrazine or any other azo dyes.

AUGMENTIN TABLET

Augmentin Indications : Tablet/Syrup: For the short-term treatment of bacterial infections at the following sites when amoxycillin resistant to b-lactamase-producing strains are suspected as the cause. In other situations, amoxycillin alone should be considered. Upper respiratory tract infections (including ear, nose and throat), in particular sinusitis, otitis media, recurrent tonsillitis. These infections are often caused by Streptococcus pneumoniae, Haemophilus influenzae*, Moraxella catarrhalis* and Streptococcus pyogenes. Lower respiratory tract infections, in particular acute exacerbations of chronic bronchitis (especially if considered severe), bronchopneumonia. These infections are often caused by Streptococcus pneumoniae, Haemophilus influenzae* and Moraxella catarrhalis*. Urinary tract infections, in particular cystitis (especially when recurrent or complicated, excluding prostatitis). These infections are often caused by Enterobacteriaceae* (mainly Escherichia coli*), Staphylococcus saprophyticus, Enterococcus sp*. Skin and soft tissue infections, in particular cellulitis and severe dental abscess with spreading cellulitis. These infections are often caused by Staphylococcus aureus*, Streptococcus pyogenes and Bacteroides sp*. A comprehensive list of sensitive organisms is provided in Microbiology under Actions. *Some members of these species of bacteria produce b-lactamase, rendering them insensitive to amoxycillin alone. Mixed infections caused by amoxycillin-susceptible organisms in conjunction with Augmentin-susceptible b-lactamase-producing organisms may be treated with Augmentin syrup 228 mg/mL and 457 mg/5 mL. These infections should not require the addition of another antibiotic resistant to b-lactamases. Augmentin IV is also indicated for the short-term treatment of bacterial infections and prophylaxis against infections which may be associated with major surgical procedures involving gastrointestinal, pelvic, head and neck, cardiac, renal, biliary tract and joint replacement surgeries.

Augmentin Dosage : Tablet: Usual Dosage for the Treatment of Infection: Adults and Children >12 years: Mild to Moderate Infections: One 375-mg tab 3 times a day or every 8 hrs; or one 625-mg tab 2 times a day, or every 12 hrs. Severe Infections: One 625-mg tab 3 times a day or every 8 hrs; or one 1-g tab 2 times a day or every 12 hrs. Therapy can be started parenterally and continued with an oral preparation. Dental Infections (eg, dentoalveolar abscess): Adults and Children >12 years:One 375-mg tab 3 times a day (or every 8 hrs) or one 625-mg tab 2 times a day (or every 12 hrs), for 5 days. Renal Impairment: Adults: The 1-g tab should only be used in patients with a creatinine clearance rate of >30 mL/min. (See Table 2.) Hepatic Impairment: Use with caution; monitor hepatic function at regular intervals. Tablets should be swallowed whole without chewing. If required, tablets may be broken in half and swallowed without chewing. Syrup: Children: 156-mg Syrup: Usual Recommended Daily Dosage: 25 mg/kg/day+ in divided doses every 8 hrs. The following presents guidance for children: Children >6 years (18-40 kg): 10 mL of the 156-mg syrup 3 times a day or every 8 hrs; 1-6 years (10-18 kg): 5 mL of the 156-mg syrup 3 times a day or every 8 hrs; <1 year: 25 mg/kg/day+, eg a 7.5-kg child would require 2 mL of the 156-mg syrup 3 times a day or every 8 hrs. In more serious infections, the dosage may be increased up to 50 mg/kg/day in divided doses every 8 hrs. +Each 25-mg Augmentin provides amoxicillin 20 mg and clavulanic acid 5 mg. 228-/457-mg Syrup: Usual Recommended Daily Dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections, eg recurrent tonsillitis, lower respiratory infections, and skin and soft tissue infections). 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, eg otitis media and sinusitis, lower respiratory tract infections, eg bronchopneumonia and urinary tract infections). Tables 2 and 3 as follows give guidance for children. Children >2 years: See Table 3. Children 2 months to 2 years: s: See Table 4. Children <2 years should be dosed according to body weight. There is insufficient experience with Augmentin syrup 228 mg/5 mL and 457 mg/5 mL to make dosage recommendations for children <2 months. Infants with Immature Kidney Function: For children with immature renal function, Augmentin syrup 228 mg/5 mL and 457 mg/5 mL are not recommended. Renal Impairment: For children with a GFR of >30 mL/min, no adjustment in dosage is required. For children with a GFR of <30 mL/min, Augmentin syrup 228 mg/5 mL and 457 mg/5 mL are not recommended. Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals. There is, as yet, insufficient evidence on which to base a dosage recommendation. To minimise potential gastrointestinal intolerance, administer the drug at the start of a meal. The absorption of Augmentin is optimised when taken at the start of a meal. Treatment should not be extended beyond 14 days without review. Instructions for Use/Handling: Glass Bottles: At time of dispensing, the dry powder should be reconstituted to form an oral suspension, as detailed in Table 5. Sachets: Single-dose sachets contain powder for a 2.5-mL dose of Augmentin syrup 457 mg/5 mL. Directions for Use: Check that the sachet is intact before use. Cut sachet along dotted line. Empty contents into a glass. Half fill sachet with water. Pour into a glass, stir to mix. Drink immediately upon reconstitution. If 2 or 4 sachets have to be taken at once, then they can be mixed in the same glass. IV Injection: Note: Patients who respond to Augmentin IV therapy can thereafter be changed to the appropriate oral presentation of Augmentin. Usual Dosage by IV Injection or Infusion: Adults and Children >12 years: Usually 1.2 g of Augmentin 8-hourly. In more serious infections, increase frequency to 6-hourly intervals. Children 3 months to 12 years: Usually, 30 mg/kg* Augmentin 8-hourly. In serious infections, increase frequency to 6-hourly intervals; 0-3 months: 30 mg/kg* Augmentin every 12 hrs in premature infants and in full-term infants during the perinatal period, increasing to 8 hrs thereafter. *Each 30-mg Augmentin IV contains amoxicillin 25 mg and clavulanic acid 5 mg. For Surgical Prophylaxis: Surgical prophylaxis with Augmentin should aim to protect the patient for the period of risk of infection. Accordingly, procedures lasting for <1 hr are successfully covered in adults by administering 1.2 g IV at induction of anaesthesia. Longer operations require subsequent doses of 1.2-g Augmentin IV (up to 4 doses in 24 hrs) and this regimen can be continued for several days if the procedure has significantly increased the risk of infection. Clear clinical signs of infection at operation will require a normal course of IV or oral Augmentin therapy postoperatively. Renal Impairment: Adults: Mild Impairment (creatinine clearance >30 mL/min): No change in dosage. Moderate Impairment (creatinine clearance 10-30 mL/min): 1.2 g IV immediately, followed by 600 mg IV 12-hourly. Severe Impairment (creatinine clearance <10 mL/min): 1.2 g IV immediately, followed by 600 mg IV 24-hourly. Dialysis decreases serum concentrations of Augmentin and an additional 600-mg IV dose may need to be given during dialysis and at the end of dialysis. Children: Similar reductions in dosage should be made for children. Treatment for adults and children should not be extended beyond 14 days without review. Preparation and Administration: Augmentin IV may be administered either by IV injection or by intermittent infusion. It is not suitable for IM administration. 600-mg Vial: To reconstitute, dissolve contents in 10 mL of Water for Injections BP (final volume 10.5 mL). 1.2-g Vial: To reconstitute, dissolve contents in 20 mL of Water for Injections BP (final volume 20.9 mL). A transient pink colouration may appear during reconstitution. Reconstituted solutions are normally a pale-straw colour. IV Injection: Administer slowly, over a period of 3-4 min. Augmentin may be injected directly into a vein or via a drip tube. IV Infusion: Add 600-mg reconstituted solution to 50-mL infusion fluid or 1.2-g reconstituted solution to 100-mL infusion fluid (eg, preferably using a minibag or in-line burette).* Appropriate infusion fluids are listed under Cautions for Usage. The infusion should be given over 30-40 min. *Solutions should be made up to full infusion volume immediately after reconstitution. Any residual antibiotic solutions should be discarded.

Augmentin Precautions : Changes in liver function tests have been observed in some patients receiving Augmentin. The clinical significance of these changes is uncertain but Augmentin should be used with caution in patients with evidence of severe hepatic dysfunction. Cholestatic jaundice, which may be severe, but is usually reversible, has been reported rarely. Signs and symptoms may not become apparent for up to 6 weeks after treatment has ceased. In patients with moderate or severe renal impairment, Augmentin dosage should be adjusted as recommended under Dosage & Administration. Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity (see Contraindications). Erythematous rashes have been associated with glandular fever in patients receiving amoxycillin. Prolonged use may also occasionally result in overgrowth of nonsusceptible organisms. Augmentin suspensions contain aspartame 12.5 mg/5 mL dose and therefore, care should be taken in phenylketonuria. Drug Abuse and Dependence: Drug dependency, addiction and recreational abuse have not been reported as a problem with Augmentin. Effects on the Ability to Drive or Operate Machinery: Adverse effects on the ability to drive or operate machinery have not been observed. Use in pregnancy & lactation: Reproduction studies in animals (mice and rats) with orally and parenterally administered Augmentin have shown no teratogenic effects. There is limited experience of the use of Augmentin in human pregnancy. As with all medicines, use should be avoided during pregnancy, especially during the 1st trimester unless considered essential by the physician. Augmentin may be administered during the period of lactation. With the exception of the risk of sensitisation, associated with the excretion of trace quantities in breast milk, there are no detrimental effects for the breastfed infant. Use in children: The tablets are not recommended in children under 12 years.

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