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Levaquin
(Cravit Brand) Levofloxacin 500mg By Daiichi Japan
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Levaquin 500mg Tablet ( Cravit Brand) |
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By Daiichi Japan |
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Generic name : Levofloxacin |
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 Levaquin 500mg Tablet ( Cravit Brand) |
10 Tablets |
$ 65 |
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Levaquin 500mg Tablet ( Cravit Brand) |
20 Tablets |
$ 130 |
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Levaquin 500mg Tablet ( Cravit Brand) |
30 Tablets |
$ 155 |
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Levaquin - CRAVIT Description
: The solution also contains the following ingredients:
Sodium chloride, sodium hydroxide, hydrochloric
acid (to make pH 4.8) and water for injection. Levofloxacin
is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic
acid hemihydrate. It has a molecular formula of
C18H20FN3O4·½H2O, molecular weight of 370.38 and
a melting point of 222-230°C (decomposition). Levofloxacin
is a light yellowish-white to yellowish-white crystals
or crystalline powder, odorless and has a bitter
taste. It is freely soluble in glacial acetic acid,
sparingly soluble in water and methanol, slightly
soluble in ethanol, and practically insoluble in
ether. It is light sensitive. Cravit IV: The data
demonstrate that from pH 0.6-5.8, the solubility
of Cravit is essentially constant (approximately
100 mg/mL), Cravit is considered soluble to freely
soluble in this pH range. Above pH 5.8, the solubility
increase rapidly to its maximum at pH 6.7 ( 272
mg/mL) and is considered freely soluble in this
range. Above pH 6.7, the solubility decrease and
reach a maximum value (about 50 mg/mL) at a pH of
approximately 6.9. Cravit has the potential to form
stable coordinate compounds with many metal ions.
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Levaquin
(Cravit Brand) Levofloxacin 500mg By Daiichi Japan
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Levaquin - CRAVIT Indications
: Treatment
of adults (³16 years) with mild, moderate and severe
infections caused by susceptible strains of the
designated microorganisms in the following conditions:
Pneumonia due to Staphylococcus aureus, Streptococcus
pneumoniae (including penicillin-resistant strains),
Haemophilus influenzae, Haemophilus parainfluenzae,
Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia
pneumoniae, Legionella pneumophila or Mycoplasma
pneumoniae. Skin and skin structure infections (mild
to moderate) including abscesses, cellulitis, furuncles,
impetigo, pyoderma and wound infections due to Staphylococcus
aureus, Streptococcus pyogenes, Enterococcus faecalis
or Proteus mirabilis. Urinary tract infections (mild
to moderate) due to Enterococcus faecalis, Enterobacter
cloacae, Escherichia coli, Klebsiella pneumoniae,
Proteus mirabilis, Pseudomonas aeruginosa or Staphylococcus
saprophyticus. Pyelonephritis (mild to moderate)
caused by Escherichia coli. Cravit: Acute sinusitis
due to Streptococcus pneumoniae, Haemophilus influenzae
or Moraxella catarrhalis. Acute exacerbation of
chronic bronchitis due to Staphylococcus aureus,
Streptococcus pneumoniae, Haemophilus influenzae,
Haemophilus parainfluenzae or Moraxella catarrhalis.
Empirical treatment for community-acquired pneumonia
most likely caused by organisms susceptible to levofloxacin.
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Levaquin - CRAVIT Dosage
: The serum creatinine should
represent a steady state of renal function. Patients
with Impaired Liver Function: No adjustment of dosage
is required since levofloxacin is not metabolised
to any relevant extent by liver and is mainly excreted
by kidneys. Elderly: No adjustment is required in
the elderly, other than that imposed by consideration
of renal function. Cravit: Adults: 300-500 mg is usually
administered orally 1-3 times a day. The dosage may
be adjusted according to the kind of infection and
symptoms. Empirical Treatment for Community-Acquired
Pneumonia: 500 mg is administered once daily. As a
general rule, the duration of treatment with Cravit
should be limited to a minimum required for the treatment
of diseases (10-14 days for sinusitis, 7 days for
chronic bronchitis, 7-14 days for pneumonia, 7-10
days for skin and skin structure infection and 10
days for urinary tract infection and pyelonephritis)
in order to avoid possible occurrence of resistant
bacteria. Cravit IV: Administer by IV infusion. It
is not for IM, intrathecal, intraperitoneal or SC
administration. The dosage depends on the type and
severity of the infection and the sensitivity of the
presumed causative pathogen. The duration of therapy
varies according to the course of the disease. As
with any antibiotic therapy in general, administration
of Cravit IV should be continued for a minimum of
48-72 hrs after the patient has become afebrile or
evidence of bacterial eradication has been obtained.
It is usually possible to switch from initial IV treatment
to the oral route after a few days. Usual Dose: 500
mg administered by slow infusion over 60 min every
24 hrs as described Tables 1 and 2. (See Tables 1
and 2.) Compatibility: Cravit IV solution for infusion
is compatible with the following solution for infusion:
0.9% Sodium Chloride Injection USP; 5% Dextrose Injection
USP, 2.5% Dextrose in Ringer Solution. Combination
solutions for parenteral nutrition (amino acids, carbohydrates,
electrolytes). |
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Levaquin - CRAVIT Warning
: Levofloxacin is more soluble than other quinolones,
adequate hydration of patients receiving levofloxacin
should be maintained to prevent the formation of highly
concentrated urine. In patients with impaired renal
function, adjustment of dosage regimen is necessary
to avoid the accumulation of levofloxacin due to decrease
clearance (see Dosage & Administration). Excessive
exposure to sunlight should be avoided. However, phototoxicity
has been observed in <0.1% of patients. Therapy should
be discontinued if phototoxicity (eg, skin eruption)
occurs. In diabetic patients, careful monitoring of
blood glucose is recommended. If a hypoglycemic reaction
occur in a patient being treated with levofloxacin,
it should be discontinued immediately and appropriate
therapy should be initiated immediately (see Adverse
Reactions). Diarrhoea, particularly if severe, persistent
and/or bloody, during or after treatment with Cravit/IV,
may be symptomatic of Clostridium difficile-associated
disease, the most severe form of which is pseudomembranous
colitis. If pseudomembranous colitis is suspected,
Cravit/IV must be stopped immediately and appropriate
specific antibiotic therapy must be started without
delay (eg, vancomycin or metronidazole). Products
inhibiting the peristalsis are contraindicated in
this clinical situation. Tendinitis, rarely observed
with quinolones, may occasionally lead to rupture,
involving Achilles tendon in particular. Elderly patients
are more prone to tendinitis. Rupture seems to be
favoured by treatment with corticosteroids. If tendinitis
is suspected, treatment with Craviit/IV must be halted
immediately, and appropriate treatment (eg, immobilisation)
must be initiated for the affected tendon. Levofloxacin
may inhibit the growth of Mycobacterium tuberculosis,
and therefore may give false-negative results in the
bacteriological diagnosis of tuberculosis. Cravit
IV: Rapid or bolus IV injection may result in hypotension.
Cravit IV should only be administered by slow IV infusion
over a period of 60 min. Effects on the Ability to
Drive or Operate Machinery: Some undesirable effects
(see Adverse Reactions) may impair the patient's ability
to concentrate and react, and therefore may constitute
a risk in situation where these abilities are of special
importance (eg, driving a car or operating machinery).
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